PROJECTS
RESEARCH
Primary Areas of Interest
REGIONALLY DEFINED BRAIN ORGANOIDS
We develop the brain organoids that represent distinct brain regions.
Now, the major goals are to generate cortical and subcortical brain organoids.
We also investigate the interaction of the regionally defined brain organoids.
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HUMAN NEURODEVELOPMENTAL DISORDERS
Human brain organoids represent the developing human brain. We use human embryonic stem cells (hESCs), or induced pluripotent stem cells (iPSCs) to study human neurodevelopmental disorders.
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Autism spectrum disorders (ASD), bipolar diseases (BP), and Rett syndrome are among the diseases we focus.
BRAIN IMMUNITY & VASCULATURE
We investigate the function of immune cells in brain in their role in neurodegenerative, autoimmune and brain tumors. How innate and adaptive immune cells interact and influence the neurons and glial cells are major research focus.
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The immune cells are targets to treat the brain diseases.
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In addition, we recapitulate the vasculature in brain organoids.
This work is a step forward to a more physiologically relevant brain organoid model.